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Health & Biotech
The three best-performing health and biotech companies in the past fortnight have all seen their shares fly on the back of positive clinical trial results — and the top two are companies trying to recover from previously disappointing trials.
Both Actinogen (ASX:ACW) and Bionomics (ASX:BNO) were the subject of shareholder scorn in the past year, as each conducted phase II trials that failed to have the desired effect.
But shareholders who stuck fat with the beleaguered biotechs are smiling now — both have had extraordinary share price gains thanks to signs their drugs might work after all.
Actinogen is the biggest winner, up 333 per cent, after reporting that higher dosages of its Alzheimer’s drug Xanamem facilitated improved cognitive function in healthy elderly patients in a Phase I trial.
The company plummeted earlier this year when it revealed that an elongated phase II trial of 10mg of Xanamem in Alzhiemer’s patients failed; the latest data suggests 20mg may work.
Similarly, Bionomics (ASX:BNO), which is trying to treat PTSD with its drug BNC210, is up 208 per cent upon optimising the dosage for a redo of its failed phase II trial.
Around this time last year the company shed two-thirds of its value when the drug didn’t work. But a re-examination in February found that some patients in the original trial included people who didn’t take the drug as intended (with food). For those that did, it remained in the patients’ bloodstream and had a positive effect on PTSD symptoms.
There haven’t been any significant falls in the past two weeks, however Smiles Inclusive (ASX:SIL) is haemorrhaging value, down 94 per cent year-on-year.
Here are all the ASX small cap health and biotech stocks and their performance in the past fortnight:
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| Code | Name | Price (3pm Thursday) | % Return (2 Weeks) | % Return (1 Year) | Market cap |
|---|---|---|---|---|---|
| ACW | ACTINOGEN MEDICAL LTD | 0.039 | 333 | -11 | $ 57,080,796.00 |
| BNO | BIONOMICS LTD | 0.11 | 208 | -35 | $ 65,362,304.00 |
| ANP | ANTISENSE THERAPEUTICS LTD | 0.08 | 64 | 344 | $ 32,347,968.00 |
| MEM | MEMPHASYS LTD | 0.068 | 52 | 394 | $ 43,419,504.00 |
| PAR | PARADIGM BIOPHARMACEUTICALS | 2.91 | 44 | 222 | $ 571,447,296.00 |
| RCE | RECCE PHARMACEUTICALS LTD | 0.33 | 43 | 94 | $ 35,352,872.00 |
| OVN | OVENTUS MEDICAL LTD | 0.76 | 35 | 133 | $ 101,160,528.00 |
| VBS | VECTUS BIOSYSTEMS LTD | 0.77 | 35 | -4 | $ 17,301,198.00 |
| BD1 | BARD1 LIFE SCIENCES LTD | 0.046 | 27 | 331 | $ 64,257,696.00 |
| BLT | BENITEC BIOPHARMA LTD | 0.056 | 27 | -66 | $ 17,842,678.00 |
| RAP | RESAPP HEALTH LTD | 0.27 | 24 | 23 | $ 172,323,232.00 |
| EHH | EAGLE HEALTH HOLDINGS LTD | 0.18 | 23 | -32 | $ 59,869,072.00 |
| SOM | SOMNOMED LTD | 2.5 | 21 | 39 | $ 163,290,832.00 |
| IDT | IDT AUSTRALIA LTD | 0.175 | 21 | 3 | $ 41,466,800.00 |
| ZLD | ZELDA THERAPEUTICS LTD | 0.083 | 20 | 19 | $ 62,859,380.00 |
| BIT | BIOTRON LTD | 0.078 | 20 | -22 | $ 50,045,004.00 |
| ATH | ALTERITY THERAPEUTICS LTD | 0.033 | 18 | -25 | $ 28,670,384.00 |
| GLH | GLOBAL HEALTH LTD | 0.17 | 17 | -13 | $ 5,725,360.50 |
| ALC | ALCIDION GROUP LTD | 0.2675 | 17 | 537 | $ 224,309,568.00 |
| IMM | IMMUTEP LTD | 0.026 | 17 | -52 | $ 94,722,976.00 |
| S66 | STAR COMBO PHARMA LTD | 0.53 | 15 | -36 | $ 45,864,400.00 |
| IBX | IMAGION BIOSYSTEMS LTD | 0.044 | 15 | -18 | $ 15,050,367.00 |
| RNO | RHINOMED LTD | 0.275 | 15 | -7 | $ 45,685,624.00 |
| KZA | KAZIA THERAPEUTICS LTD | 0.525 | 15 | 30 | $ 33,570,004.00 |
| RAC | RACE ONCOLOGY LTD | 0.13 | 13 | 18 | $ 13,095,656.00 |
| VTI | VISIONEERING TECH-CDI | 0.075 | 13 | -55 | $ 27,939,460.00 |
| DXB | DIMERIX LTD | 0.105 | 13 | 0 | $ 16,673,941.00 |
| ATX | AMPLIA THERAPEUTICS LTD | 0.092 | 13 | -70 | $ 4,785,352.50 |
| AVH | AVITA MEDICAL LTD | 0.565 | 13 | 391 | $ 1,095,637,632.00 |
| BWX | BWX LTD | 4.055 | 12 | 11 | $ 495,757,056.00 |
| CGS | COGSTATE LTD | 0.295 | 11 | -48 | $ 43,882,236.00 |
| LCT | LIVING CELL TECHNOLOGIES LTD | 0.022 | 11 | -29 | $ 11,428,820.00 |
| SVA | SIMAVITA LTD-CDI | 0.01 | 11 | -67 | $ 4,177,781.25 |
| PBP | PROBIOTEC LTD | 1.885 | 10 | 28 | $ 122,153,408.00 |
| OIL | OPTISCAN IMAGING LTD | 0.044 | 10 | -29 | $ 20,687,868.00 |
| CYP | CYNATA THERAPEUTICS LTD | 1.59 | 10 | 32 | $ 160,422,688.00 |
| ANR | ANATARA LIFESCIENCES LTD | 0.23 | 10 | -51 | $ 11,365,044.00 |
| VLS | VITA LIFE SCIENCES LTD | 0.64 | 9 | -16 | $ 35,639,844.00 |
| VHT | VOLPARA HEALTH TECHNOLOGIES | 1.635 | 9 | 84 | $ 357,622,496.00 |
| OSP | OSPREY MEDICAL INC-CDI | 0.049 | 9 | -78 | $ 21,158,072.00 |
| ICS | ICSGLOBAL LTD | 1.25 | 9 | 15 | $ 13,230,024.00 |
| JHC | JAPARA HEALTHCARE LTD | 1.195 | 7 | -5 | $ 320,696,800.00 |
| PAA | PHARMAUST LTD | 0.15 | 7 | 372 | $ 42,207,180.00 |
| NTI | NEUROTECH INTERNATIONAL LTD | 0.015 | 7 | -87 | $ 2,036,158.00 |
| CDY | CELLMID LTD | 0.225 | 7 | -39 | $ 19,648,226.00 |
| CAJ | CAPITOL HEALTH LTD | 0.235 | 7 | -10 | $ 176,731,872.00 |
| SDI | SDI LTD | 0.83 | 7 | 45 | $ 96,281,080.00 |
| MVP | MEDICAL DEVELOPMENTS INTERNA | 4.96 | 6 | 11 | $ 325,618,240.00 |
| IPD | IMPEDIMED LTD | 0.175 | 6 | -61 | $ 91,306,248.00 |
| PXS | PHARMAXIS LTD | 0.2025 | 5 | -34 | $ 76,961,080.00 |
| PGC | PARAGON CARE LTD | 0.39 | 5 | -45 | $ 135,154,112.00 |
| MX1 | MICRO-X LTD | 0.29 | 5 | -19 | $ 50,331,208.00 |
| OCC | ORTHOCELL LTD | 0.405 | 5 | 56 | $ 63,281,900.00 |
| PCK | PAINCHEK LTD | 0.34 | 5 | 530 | $ 313,997,280.00 |
| NSB | NEUROSCIENTIFIC BIOPHARMACEU | 0.25 | 4 | 56 | $ 19,957,750.00 |
| NOX | NOXOPHARM LTD | 0.395 | 4 | -38 | $ 51,338,264.00 |
| AZV | AZURE HEALTHCARE LTD | 0.081 | 4 | -10 | $ 18,849,738.00 |
| MVF | MONASH IVF GROUP LTD | 1.0675 | 3 | 4 | $ 248,754,112.00 |
| JHL | JAYEX HEALTHCARE LTD | 0.031 | 3 | 35 | $ 5,351,003.50 |
| ONT | 1300 SMILES LTD | 6.25 | 3 | 1 | $ 147,989,904.00 |
| PNV | POLYNOVO LTD | 2.2 | 2 | 283 | $ 1,467,615,488.00 |
| MDR | MEDADVISOR LTD | 0.045 | 2 | 15 | $ 64,548,972.00 |
| ONE | ONEVIEW HEALTHCARE PLC-CDI | 0.28 | 2 | -80 | $ 48,408,216.00 |
| 1ST | 1ST GROUP LTD | 0.06 | 2 | 94 | $ 22,389,326.00 |
| OPT | OPTHEA LTD | 3.5 | 0 | 483 | $ 896,037,632.00 |
| CDX | CARDIEX LTD | 0.027 | 0 | -29 | $ 19,474,062.00 |
| ALT | ANALYTICA LTD | 0.003 | 0 | -50 | $ 10,558,837.00 |
| SUD | SUDA PHARMACEUTICALS LTD | 0.0035 | 0 | -8 | $ 12,447,301.00 |
| BPH | BPH ENERGY LTD | 0.002 | 0 | 167 | $ 5,980,555.50 |
| SCU | STEMCELL UNITED LTD | 0.015 | 0 | -38 | $ 9,624,125.00 |
| HCT | HOLISTA COLLTECH LTD | 0.063 | 0 | -7 | $ 14,744,462.00 |
| ACR | ACRUX LTD | 0.185 | 0 | -20 | $ 30,011,888.00 |
| SDX | SIENNA CANCER DIAGNOSTICS LT | 0.049 | 0 | -42 | $ 11,562,207.00 |
| GTG | GENETIC TECHNOLOGIES LTD | 0.006 | 0 | -40 | $ 14,690,671.00 |
| 1AD | ADALTA LTD | 0.15 | 0 | -42 | $ 23,002,280.00 |
| M7T | MACH7 TECHNOLOGIES LTD | 0.67 | 0 | 235 | $ 97,697,864.00 |
| ADO | ANTEO DIAGNOSTICS LTD | 0.013 | 0 | 5 | $ 19,425,996.00 |
| AMT | ALLEGRA ORTHOPAEDICS LTD | 0.11 | 0 | -45 | $ 10,951,496.00 |
| IHL | IMPRESSION HEALTHCARE LTD | 0.086 | 0 | 378 | $ 51,931,612.00 |
| MXC | MGC PHARMACEUTICALS LTD | 0.039 | 0 | -20 | $ 54,668,440.00 |
| FTT | FACTOR THERAPEUTICS LTD | 0.0035 | 0 | -96 | $ 3,128,507.00 |
| OBJ | OBJ LTD | 0.016 | 0 | -27 | $ 28,951,402.00 |
| PSQ | PACIFIC SMILES GROUP LTD | 1.565 | 0 | 10 | $ 240,149,568.00 |
| TLX | TELIX PHARMACEUTICALS LTD | 1.425 | -1 | 74 | $ 378,653,600.00 |
| THC | THC GLOBAL GROUP LTD | 0.44 | -1 | -20 | $ 60,009,056.00 |
| NVL | NATIONAL VETERINARY CARE LTD | 2.33 | -1 | 5 | $ 160,803,280.00 |
| HLA | HEALTHIA LTD | 0.875 | -2 | -28 | $ 55,155,324.00 |
| PTX | PRESCIENT THERAPEUTICS LTD | 0.061 | -2 | -19 | $ 21,684,334.00 |
| GSS | GENETIC SIGNATURES LTD | 1.08 | -2 | 44 | $ 112,384,192.00 |
| KKT | KONEKT LTD | 0.265 | -2 | -11 | $ 28,033,512.00 |
| NEU | NEUREN PHARMACEUTICALS LTD | 1.985 | -2 | 70 | $ 206,340,032.00 |
| MMJ | MMJ GROUP HOLDINGS LTD | 0.24 | -2 | -19 | $ 54,174,956.00 |
| CMP | COMPUMEDICS LTD | 0.615 | -3 | 28 | $ 103,640,328.00 |
| UBI | UNIVERSAL BIOSENSORS INC-CDI | 0.19 | -3 | -21 | $ 33,696,340.00 |
| CPH | CRESO PHARMA LTD | 0.3825 | -3 | -32 | $ 57,965,708.00 |
| ELX | ELLEX MEDICAL LASERS LTD | 0.54 | -4 | -26 | $ 77,544,616.00 |
| UCM | USCOM LTD | 0.12 | -4 | -23 | $ 17,092,354.00 |
| PYC | PHYLOGICA LTD | 0.047 | -4 | 52 | $ 109,928,552.00 |
| PAB | PATRYS LTD | 0.022 | -4 | -41 | $ 23,596,988.00 |
| IMU | IMUGENE LTD | 0.022 | -4 | 5 | $ 79,416,648.00 |
| NXS | NEXT SCIENCE LTD | 3.05 | -4 | $ 543,030,592.00 | |
| IMC | IMMURON LTD | 0.19 | -5 | -40 | $ 18,561,996.00 |
| PAL | PALLA PHARMA LTD | 1 | -5 | -33 | $ 81,085,592.00 |
| SKN | SKIN ELEMENTS LTD | 0.019 | -5 | -63 | $ 3,249,276.50 |
| ESE | ESENSE-LAB LTD-CDI | 0.019 | -5 | -47 | $ 3,611,461.25 |
| LSH | LIFESPOT HEALTH LTD | 0.055 | -5 | -32 | $ 4,266,277.50 |
| BOT | BOTANIX PHARMACEUTICALS LTD | 0.2375 | -6 | 153 | $ 226,658,528.00 |
| CYC | CYCLOPHARM LTD | 1.2 | -6 | 14 | $ 82,678,648.00 |
| TDL | TBG DIAGNOSTICS LTD | 0.03 | -6 | -48 | $ 6,527,618.50 |
| IVX | INVION LTD | 0.015 | -7 | -50 | $ 77,008,488.00 |
| PIQ | PROTEOMICS INTERNATIONAL LAB | 0.33 | -7 | 32 | $ 27,067,242.00 |
| AGH | ALTHEA GROUP HOLDINGS LTD | 0.68 | -8 | 19 | $ 170,162,992.00 |
| RHT | RESONANCE HEALTH LTD | 0.12 | -8 | 380 | $ 51,256,072.00 |
| MEB | MEDIBIO LTD | 0.012 | -8 | -79 | $ 11,941,560.00 |
| AHX | APIAM ANIMAL HEALTH LTD | 0.48 | -8 | -22 | $ 49,890,368.00 |
| RHY | RHYTHM BIOSCIENCES LTD | 0.165 | -8 | 10 | $ 16,623,750.00 |
| RSH | RESPIRI LTD | 0.084 | -9 | -11 | $ 45,269,532.00 |
| AC8 | AUSCANN GROUP HOLDINGS LTD | 0.34 | -9 | -65 | $ 107,796,104.00 |
| CAN | CANN GROUP LTD | 1.525 | -10 | -44 | $ 219,087,568.00 |
| MDC | MEDLAB CLINICAL LTD | 0.435 | -10 | -8 | $ 92,606,808.00 |
| CP1 | CANNPAL ANIMAL THERAPEUTICS | 0.15 | -12 | -6 | $ 13,968,750.00 |
| LBT | LBT INNOVATIONS LTD | 0.11 | -12 | 0 | $ 25,887,376.00 |
| CTE | CRYOSITE LTD | 0.044 | -12 | -31 | $ 2,061,820.75 |
| OSL | ONCOSIL MEDICAL LTD | 0.065 | -13 | -67 | $ 40,996,072.00 |
| RGS | REGENEUS LTD | 0.069 | -14 | -62 | $ 18,518,712.00 |
| FFC | FARMAFORCE LTD | 0.12 | -14 | 20 | $ 15,452,518.00 |
| BXN | BIOXYNE LTD | 0.018 | -14 | -51 | $ 11,522,617.00 |
| NC6 | NANOLLOSE LTD | 0.064 | -15 | -42 | $ 4,799,999.50 |
| EXL | ELIXINOL GLOBAL LTD | 2.05 | -16 | 4 | $ 275,788,224.00 |
| AVE | AVECHO BIOTECHNOLOGY LTD | 0.005 | -17 | -78 | $ 7,887,287.00 |
| ADR | ADHERIUM LTD | 0.03 | -18 | -61 | $ 4,698,863.50 |
| NHL | NOVITA HEALTHCARE LTD | 0.01 | -23 | -70 | $ 6,493,052.00 |
| SIL | SMILES INCLUSIVE LTD | 0.05 | -27 | -94 | $ 3,064,650.50 |
| DVL | DORSAVI LTD | 0.043 | -28 | -50 | $ 8,772,722.00 |
| GMV | G MEDICAL INNOVATION HOLDING | 0.081 | -33 | -79 | $ 32,696,880.00 |
Health & Biotech
Health & Biotech
Health & Biotech
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