It’s been a mixed two weeks for small-cap health companies, with only 38 companies gaining ground, 74 losing it and 21 flatlining.

Analytica Limited (ASX:ALT) was the biggest gainer, up 25% from 8 to 20 July, followed by  Rhinomed (ASX:RNO) up 23.53% and Stemcell United (ASX:SCU) up 18.75% – but all on no news.

The next cab off the ranks was Rhythm Biosciences (ASX:RHY) which rose 16.28% on the news it has established a US entity – IchorDX, Inc – as part of its plans to expand into the American market.

The company says the US represents one of the largest diagnostic markets in the world, with a current addressable market of over 94 million people.

“The establishment of IchorDX, Inc., in the US demonstrates our commitment to accelerate our international expansion plans, offer additional optionality to our corporate structure and aim to create a global footprint for Rhythm’s transformative cancer detection technology,” Rhythm CEO Glenn Gilbert said.

“The reality is that the global need for a simple and accurate mass screening blood test for colorectal cancer is growing. This first step to enter the US market moves Rhythm closer to meeting this need.”

Plus, the market could grow in the short term by a further 21%, following the US Preventative Services Task Force recommendation that the colorectal cancer screening age be reduced from 50 to 45 years of age.

LBT Innovations (ASX:LBT) was up 11.11% after it presented data from five clinical studies featuring the Automated Plate Assessment System (APAS) at the European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) from 9-12 July.

“Application of the APAS® technology to early culture reads has the potential to further disrupt the current application of testing in clinical laboratories, with the potential to improve patient care through faster turnaround of results,” LBT scientific director Dr Steven Giglio said.

Up 10.87% was Recce Pharma (ASX:RCE) which recently announced multiple patients have been dosed with RECCE 327 (R327) in a topical Phase I/II clinical trial at the Fiona Stanley Hospital Burns Unit in Perth, Western Australia.

The company also announced R327 had demonstrated “outstanding efficacy against necrotizing fasciitis ‘flesh eating’ bacteria” – as well as an anti-viral patent being granted in China for its synthetic anti-infectives.

Lifespot Health (ASX:LSH) rose 10.53% after news it had appointed two new board members in Dr Andrew Saich and Darryl Davies.

Proteomics (ASX:PIQ) jumped 9.73% off the back of news its diabetes treatment lowers the PromarkerD scores of patients with type 2 diabetes taking canagliflozin, an SGLT2-inhibitor diabetes drug.

And Hexima (ASX:HXL) was up 9.09% with plans to present further analysis of the clinical data from its Phase I/IIa clinical trial of pezadeftide (HXP124) for the treatment of onychomycosis at the upcoming American Podiatric Medical Association (APMA) meeting in Aurora, Colorado.

Then there was MGC Pharma (ASX:MXC), up 7.89% after submitting a patent application for its cannabinoid drug delivery system to the European IP office.

Here’s a table showing how ASX-listed healthcare stocks have been performing.

Code Company Price %Wk %Yr MktCap
ALT Analytica Limited 0.0025 25.00% 25.00% $11,534,503
RNO Rhinomed Ltd 0.21 23.53% 159.26% $53,299,918
SCU Stemcell United Ltd 0.019 18.75% 26.67% $18,779,772
RHY Rhythm Biosciences 1 16.28% 988.44% $206,214,227
EPN Epsilon Healthcare 0.15 15.38% -45.45% $27,942,508
S66 Star Combo 0.29 13.73% -23.68% $39,066,616
AT1 Atomo Diagnostics 0.185 12.12% -54.88% $77,651,164
AVE Avecho Biotech Ltd 0.02 11.11% 185.71% $36,722,331
LBT LBT Innovations 0.11 11.11% -26.67% $33,248,244
RCE Recce Pharmaceutical 1.02 10.87% -26.62% $166,826,733
LSH Lifespot Health Ltd 0.105 10.53% 170.42% $16,846,696
PIQ Proteomics Int Lab 1.015 9.73% 120.65% $108,362,051
HXL Hexima 0.18 9.09% -40.98% $22,268,896
MXC Mgc Pharmaceuticals 0.041 7.89% 70.83% $92,990,042
MEM Memphasys Ltd 0.07 7.69% -27.08% $53,184,172
4DX 4Dmedical Limited 1.49 7.58% 0.00% $310,829,262
ZNO Zoono Group Ltd 0.725 7.41% -69.54% $117,966,211
OSP Osprey Med Inc 0.015 7.14% -68.09% $38,486,704
GLH Global Health Ltd 0.525 6.06% 84.21% $26,002,245
MVF Monash IVF Group Ltd 0.8575 5.86% 61.79% $327,293,266
IHL Incannex Healthcare 0.275 5.77% 292.86% $291,591,509
NTI Neurotech Intl 0.056 5.66% 460.00% $39,021,871
1ST 1St Group Ltd 0.021 5.00% -44.74% $8,916,955
MMJ MMJ Group Hlds Ltd 0.085 4.94% -19.05% $19,086,181
RAP Resapp Health Ltd 0.045 4.65% -67.86% $37,804,671
PGC Paragon Care Limited 0.285 3.64% 62.86% $97,986,735
VBS Vectus Biosystems 1.345 3.46% 97.79% $42,576,505
SHG Singular Health 0.3 3.45% 0.00% $18,605,545
CDY Cellmid Limited 0.061 3.39% -53.18% $11,058,403
IDT IDT Australia Ltd 0.325 3.17% 116.67% $76,755,254
CPH Creso Pharma Ltd 0.1375 1.85% 358.33% $160,778,469
HCT Holista CollTech Ltd 0.059 1.72% -28.92% $15,970,247
BPH BPH Energy Ltd 0.074 1.37% 401.90% $47,874,196
CYC Cyclopharm Limited 1.68 1.20% 14.29% $156,869,703
BWX BWX Limited 5.14 1.18% 18.43% $719,253,770
RAC Race Oncology Ltd 3.55 1.14% 260.41% $506,846,959
NEU Neuren Pharmaceut. 1.595 0.95% 31.82% $182,226,892
ARX Aroa Biosurgery 1.21 0.83% 0.00% $365,807,475
AC8 Auscann Grp Hlgs Ltd 0.11 0.00% -26.67% $46,257,447
ADR Adherium Ltd 0.018 0.00% -30.77% $38,263,196
AHK Ark Mines Limited 0.034 0.00% 0.00% $1,778,920
ANP Antisense Therapeut. 0.2 0.00% 81.82% $112,022,887
ATX Amplia Therapeutics 0.21 0.00% 31.25% $26,212,481
BNO Bionomics Limited 0.185 0.00% 217.03% $191,443,381
CAJ Capitol Health 0.37 0.00% 76.19% $375,255,592
CDX Cardiex Limited 0.068 0.00% 112.50% $63,896,633
DVL Dorsavi Ltd 0.028 0.00% 4.59% $9,826,112
FFC Farmaforce Ltd 0.067 0.00% 21.82% $8,755,626
GSS Genetic Signatures 1.34 0.00% -44.40% $192,924,782
GTG Genetic Technologies 0.008 0.00% -30.43% $72,133,814
ICS ICSGlobal Limited 0.575313 0.00% 28.82% $6,054,605
IMC Immuron Limited 0.16 0.00% -27.27% $36,359,455
IVX Invion Ltd 0.014 0.00% 55.56% $77,553,592
LCT Living Cell Tech. 0.014 0.00% -12.50% $8,000,174
MDR Medadvisor Limited 0.3 0.00% -37.89% $113,214,905
OIL Optiscan Imaging 0.225 0.00% 378.72% $141,831,938
PAL Palla Pharma Ltd 0.38 0.00% -54.33% $59,907,870
PBP Probiotec Limited 2.1 0.00% 3.96% $162,419,250
VHT Volpara Health Tech 1.14 0.00% -17.99% $291,525,494
PAA Pharmaust Limited 0.093 -1.06% -54.63% $30,406,072
SDI SDI Limited 0.88 -1.12% 26.62% $104,601,666
VTI Vision Tech, Inc 1.12 -1.32% -37.78% $27,771,713
ONE Oneview Healthcare 0.37 -1.33% 987.08% $155,975,491
AGH Althea Group 0.335 -1.47% -6.94% $86,583,268
RSH Respiri Limited 0.067 -1.47% -53.79% $47,707,492
NOX Noxopharm Limited 0.6 -1.64% 81.82% $177,256,362
OSL Oncosil Medical 0.059 -1.67% -48.70% $48,637,941
ONT 1300 Smiles Limited 6.88 -1.71% 33.85% $162,196,930
ACR Acrux Limited 0.1325 -1.85% -17.19% $36,829,701
NXS Next Science Limited 1.55 -1.90% 21.09% $314,778,515
CGS Cogstate Ltd 1.4 -2.10% 250.00% $233,399,072
BD1 Bard1 Life Sciences 1.805 -2.17% 100.56% $145,703,221
PAR Paradigm Bio. 1.97 -2.48% -31.12% $444,232,947
APH AP Hemp Ltd 0.38 -2.56% 181.48% $29,799,953
IBX Imagion Biosys Ltd 0.0875 -2.78% 82.29% $90,711,849
CBL Control Bionics 0.64 -3.03% 0.00% $31,637,905
MDC Medlab Clinical Ltd 0.16 -3.03% 14.29% $54,748,107
PCK Painchek Ltd 0.059 -3.28% -48.70% $65,354,678
AHC Austco Healthcare 0.145 -3.33% 113.24% $44,049,287
BIT Biotron Limited 0.058 -3.33% -42.00% $41,414,030
BXN Bioxyne Ltd 0.029 -3.33% 163.64% $18,564,217
DOC Doctor Care Anywhere 0.855 -3.93% 0.00% $148,739,257
CYP Cynata Therapeutics 0.485 -3.96% -30.51% $71,638,297
JHC Japara Healthcare Lt 1.21 -3.97% 146.94% $331,386,687
EXL Elixinol Wellness 0.12 -4.00% -25.00% $37,807,578
ZLD Zelira Therapeutics 0.048 -4.00% -9.43% $57,135,502
VLS Vita Life Sciences.. 1.07 -4.04% 94.55% $55,811,769
ACW Actinogen Medical 0.11 -4.35% 388.02% $182,661,440
NSB Neuroscientific 0.32 -4.48% 48.84% $47,345,642
NC6 Nanollose Limited 0.085 -4.49% 102.38% $12,935,714
ILA Island Pharma 0.315 -4.55% 0.00% $14,171,245
IMU Imugene Limited 0.315 -4.55% 728.95% $1,621,937,450
OVN Oventus Medical Ltd 0.105 -4.55% -59.62% $26,589,919
KZA Kazia Therapeutics 1.23 -4.65% 156.70% $168,341,305
IMM Immutep Ltd 0.5 -4.76% 177.78% $377,817,232
IPD Impedimed Limited 0.1 -4.76% 47.06% $156,869,632
RGS Regeneus Ltd 0.075 -5.06% -12.79% $22,765,377
RHT Resonance Health 0.165 -5.71% 10.00% $78,344,837
TRU Truscreen 0.064 -5.88% 0.00% $23,223,440
OPT Opthea Limited 1.245 -6.04% -44.67% $438,754,426
MX1 Micro-X Limited 0.31 -6.06% 110.17% $147,104,557
CMP Compumedics Limited 0.385 -6.10% -8.33% $68,207,735
ADO Anteotech Ltd 0.225 -6.25% 603.13% $449,240,590
TLX Telix Pharmaceutical 5.25 -6.42% 286.03% $1,427,830,679
CHM Chimeric Therapeutic 0.29 -6.45% 0.00% $60,034,161
PYC PYC Therapeutics 0.145 -6.45% 27.03% $477,138,915
ALC Alcidion Group Ltd 0.36 -6.49% 132.26% $377,304,859
CTE Cryosite Limited 0.4 -6.98% 185.71% $18,743,825
PSQ Pacific Smiles Grp 2.4 -6.98% 53.85% $394,167,387
OCC Orthocell Limited 0.515 -7.21% 49.28% $100,056,679
UBI Universal Biosensors 0.75 -7.41% 240.91% $135,924,065
EYE Nova EYE Medical Ltd 0.3 -7.69% -14.63% $43,105,841
ICR Intelicare Holdings 0.175 -7.89% -58.82% $8,451,114
DXB Dimerix Ltd 0.23 -8.00% -31.34% $47,519,831
CAN Cann Group Ltd 0.365 -8.75% -49.31% $102,827,439
PXS Pharmaxis Ltd 0.081 -8.99% -5.81% $37,139,781
AMT Allegra Orthopaedics 0.2 -9.09% -16.67% $20,891,841
SOM SomnoMed Limited 2.25 -9.27% 73.75% $192,001,611
MVP Medical Developments 4.03 -9.44% -35.21% $297,886,329
PNV Polynovo Limited 2.155 -9.45% -4.65% $1,408,756,534
BOT Botanix Pharma Ltd 0.076 -10.59% 49.02% $73,958,798
PTX Prescient Ltd 0.21 -10.64% 262.07% $134,704,302
TD1 Tali Digital Limited 0.033 -10.81% 26.92% $30,752,891
EZZ EZZ Life Science 0.41 -10.87% 0.00% $5,220,000
MEB Medibio Limited 0.008 -11.11% -33.33% $14,360,492
NYR Nyrada Inc. 0.295 -11.94% 55.26% $35,027,311
JTL Jayex Technology Ltd 0.029 -12.12% 0.00% $6,393,160
OSX Osteopore Limited 0.42 -12.50% -31.15% $33,556,254
M7T Mach7 Tech Limited 0.9 -12.62% 9.09% $227,037,807
ATH Alterity Therap Ltd 0.033 -13.16% -10.81% $81,833,736
PAB Patrys Limited 0.047 -14.55% 264.01% $89,160,248
SUD Suda Pharmaceuticals 0.053 -17.19% 76.67% $27,406,739
1AD Adalta Limited 0.115 -17.86% 16.10% $33,099,243

Flat this fortnight was Auscann (ASX:AC8) even after news it had submitted its first module to the Australian Pesticides and Veterinary Medicines Association (APVMA) to commence the submission of its dossier for the registration of DermaCann – in development for anti-inflammatory and immune support in dogs with dermatological conditions.

Apparently, no one cares much that there are approximately 1 million dogs in Australia who suffer from dermatological conditions…

Maybe investors will perk up a bit when they realise the global canine skin and dermatitis market is worth an estimated US$1.5 billion globally.

Trailing the flatline pack was Adherium (ASX:ADR) with news the off-market takeover bid from Respiri (ASX:RSH) had lapsed.

Who’s the biggest loser?

Adalta (ASX:1AD) was the biggest loser, down 17.86% following the news it plans to progress the inhaled version of its AD-214 treatment into efficacy studies for Idiopathic Pulmonary Fibrosis (IPF).

It was followed closely by Suda Pharma (ASX:SUD), down 17.19% on no news.

Patrys (ASX:PAB) dropped 14.55% despite new data from non-clinical studies confirming its full-sized IgG deoxymab antibody, PAT-DX3, is able to cross the blood-brain barrier (BBB) in an animal model of primary brain cancer (glioblastoma multiforme, GBM).

And Alterity Therapeutics (ASX:ATH) followed, down 13.16% even after publishing data demonstrating its ATH434 treatment for Multiple System Atrophy (MSA) is neuroprotective and improves motor function.