A one-day gain of 148 per cent has Opthea as comfortably the best-performing small cap health or biotech stock on the ASX at a time when the majority are trending downwards.

Stockhead reported today on Opthea’s (ASX:OPT) positive results from its Phase IIb trial of its OPT-302 drug, designed to fight wet age-related macular degeneration (AMD).

The company’s shares jumped to $1.90, a 148 per cent gain, though they hit as high as $2.25.

The trial examined whether OPT-302, when combined with Lucentis, a standard treatment for wet AMD, achieved a statistically significant vision benefit over patients receiving just Lucentis. It enrolled 366 patients over 24 weeks.

The results were conclusive: patients receiving OPT-302 gained a mean of 14.2 letters of vision from baseline on a standardised eye chart at 24 weeks, compared with 10.8 letters for the control group.

CEO Megan Baldwin told Stockhead the company would now design third-phase studies.

“We’re designing [Phase III] with the input of US regulators, but we can move forward knowing we have good solid data…and sufficient capital to be undertaking these activities,” she said.

The next-best performing health company in the past fortnight was Race Oncology (ASX:RAC), up 40 per cent on news the first leukaemia patient had been treated in its clinical trial of Bisantrene.

Bisantrene is a chemotherapy drug that was the subject of more than 40 clinical studies during the 1980s and 1990s before the drug was abandoned after a series of pharmaceutical mergers.

Overall, the ASX’s near-140 health and biotech stocks have lost 4 per cent in the past fortnight, with 89 stocks losing ground. Only 31 saw gains, while 15 were stable.

Here are the ASX’s near-140 small cap health and biotech stocks and their performance in the past fortnight:

Code Name Price (3pm Thursday) Market Cap % Return (2 Weeks) % Return YTD
OPT OPTHEA LTD 1.9 $ 215,743,840.00 148 287
RAC RACE ONCOLOGY LTD 0.072 $ 5,844,799.50 40 -11
IHL IMPRESSION HEALTHCARE LTD 0.079 $ 48,654,640.00 34 394
PYC PHYLOGICA LTD 0.04 $ 87,942,840.00 24 29
IMU IMUGENE LTD 0.024 $ 83,026,496.00 21 28
SOM SOMNOMED LTD 2.1 $ 131,260,712.00 20 14
OSL ONCOSIL MEDICAL LTD 0.065 $ 40,996,072.00 18 -65
FTT FACTOR THERAPEUTICS LTD 0.0035 $ 3,649,924.75 17 75
MDC MEDLAB CLINICAL LTD 0.495 $ 106,605,512.00 16 34
HLA HEALTHIA LTD 1.05 $ 66,816,736.00 15 8
AVE AVECHO BIOTECHNOLOGY LTD 0.004 $ 6,309,829.50 14 -20
SUD SUDA PHARMACEUTICALS LTD 0.005 $ 16,003,672.00 13 -21
ANP ANTISENSE THERAPEUTICS LTD 0.05 $ 19,324,760.00 12 77
MEB MEDIBIO LTD 0.02 $ 5,676,030.00 11 -5
PAA PHARMAUST LTD 0.075 $ 21,016,590.00 10 107
HCT HOLISTA COLLTECH LTD 0.069 $ 16,148,697.00 10 19
AMT ALLEGRA ORTHOPAEDICS LTD 0.125 $ 11,947,086.00 9 -40
VBS VECTUS BIOSYSTEMS LTD 0.375 $ 8,767,498.00 7 -36
FFC FARMAFORCE LTD 0.16 $ 20,448,156.00 7 39
LSH LIFESPOT HEALTH LTD 0.064 $ 5,119,532.50 6 10
PCK PAINCHEK LTD 0.18 $ 159,977,168.00 6 349
NVL NATIONAL VETERINARY CARE LTD 2.45 $ 158,123,216.00 5 21
AZV AZURE HEALTHCARE LTD 0.073 $ 16,988,036.00 4 4
RAP RESAPP HEALTH LTD 0.15 $ 107,919,608.00 3 48
NEU NEUREN PHARMACEUTICALS LTD 1.435 $ 148,048,976.00 3 3
OVN OVENTUS MEDICAL LTD 0.48 $ 57,745,084.00 2 76
BLT BENITEC BIOPHARMA LTD 0.053 $ 13,365,530.00 2 -50
VTI VISIONEERING TECH-CDI 0.062 $ 24,347,244.00 2 -61
MDR MEDADVISOR LTD 0.046 $ 63,175,592.00 1 31
PSQ PACIFIC SMILES GROUP LTD 1.215 $ 184,671,968.00 1 -3
VLS VITA LIFE SCIENCES LTD 0.705 $ 39,327,944.00 1 -13
CAJ CAPITOL HEALTH LTD 0.225 $ 169,057,856.00 0 -16
IVX INVION LTD 0.015 $ 82,509,096.00 0 -17
ACW ACTINOGEN MEDICAL LTD 0.0085 $ 10,073,082.00 0 -80
ALT ANALYTICA LTD 0.0035 $ 14,078,449.00 0 -20
LCT LIVING CELL TECHNOLOGIES LTD 0.025 $ 14,286,025.00 0 -43
CGS COGSTATE LTD 0.195 $ 26,990,134.00 0 -68
IMM IMMUTEP LTD 0.022 $ 85,057,368.00 0 -21
NHL NOVITA HEALTHCARE LTD 0.013 $ 4,942,357.00 0 -62
OIL OPTISCAN IMAGING LTD 0.046 $ 21,628,224.00 0 2
BPH BPH ENERGY LTD 0.001 $ 2,543,277.75 0 0
PTX PRESCIENT THERAPEUTICS LTD 0.043 $ 16,953,206.00 0 -37
ATH ALTERITY THERAPEUTICS LTD 0.027 $ 23,457,586.00 0 -18
SCU STEMCELL UNITED LTD 0.016 $ 10,265,734.00 0 -16
MVF MONASH IVF GROUP LTD 1.425 $ 339,531,680.00 0 49
ICS ICSGLOBAL LTD 1.005 $ 10,636,939.00 0 12
CPH CRESO PHARMA LTD 0.425 $ 62,133,176.00 -1 -16
ONT 1300 SMILES LTD 6.22 $ 147,279,552.00 -1 -2
SDX SIENNA CANCER DIAGNOSTICS LT 0.058 $ 16,765,200.00 -2 -3
DVL DORSAVI LTD 0.049 $ 9,996,822.00 -2 -21
IBX IMAGION BIOSYSTEMS LTD 0.047 $ 15,214,150.00 -2 57
RCE RECCE PHARMACEUTICALS LTD 0.22 $ 22,497,282.00 -2 20
JHC JAPARA HEALTHCARE LTD 1 $ 267,247,328.00 -2 -9
CP1 CANNPAL ANIMAL THERAPEUTICS 0.18 $ 17,228,124.00 -3 48
ACR ACRUX LTD 0.18 $ 29,983,988.00 -3 0
ALC ALCIDION GROUP LTD 0.155 $ 121,600,672.00 -3 233
AHX APIAM ANIMAL HEALTH LTD 0.445 $ 47,124,488.00 -3 -9
OCC ORTHOCELL LTD 0.425 $ 65,562,020.00 -3 193
PBP PROBIOTEC LTD 1.6 $ 96,055,480.00 -4 6
MEM MEMPHASYS LTD 0.048 $ 29,773,376.00 -4 74
BOT BOTANIX PHARMACEUTICALS LTD 0.2275 $ 185,766,768.00 -4 243
PXS PHARMAXIS LTD 0.22 $ 86,749,472.00 -4 -17
MX1 MICRO-X LTD 0.315 $ 51,719,208.00 -5 7
BXN BIOXYNE LTD 0.02 $ 12,802,908.00 -5 -39
BNO BIONOMICS LTD 0.039 $ 21,242,750.00 -5 -63
NOX NOXOPHARM LTD 0.44 $ 54,008,600.00 -5 2
BIT BIOTRON LTD 0.086 $ 49,443,588.00 -6 -28
ELX ELLEX MEDICAL LASERS LTD 0.57 $ 81,852,624.00 -7 -17
AC8 AUSCANN GROUP HOLDINGS LTD 0.44 $ 133,159,888.00 -7 -27
ZLD ZELDA THERAPEUTICS LTD 0.076 $ 58,315,328.00 -7 48
CYP CYNATA THERAPEUTICS LTD 1.66 $ 169,378,192.00 -7 28
1ST 1ST GROUP LTD 0.08 $ 28,786,276.00 -8 179
IMC IMMURON LTD 0.125 $ 20,329,804.00 -8 -43
OSP OSPREY MEDICAL INC-CDI 0.07 $ 29,794,018.00 -8 -40
PGC PARAGON CARE LTD 0.465 $ 153,737,808.00 -8 -27
PAL PALLA PHARMA LTD 1.22 $ 96,491,856.00 -8 3
CYC CYCLOPHARM LTD 1.36 $ 93,702,464.00 -8 24
UBI UNIVERSAL BIOSENSORS INC-CDI 0.22 $ 39,016,812.00 -8 0
PAB PATRYS LTD 0.022 $ 23,596,988.00 -8 -19
KZA KAZIA THERAPEUTICS LTD 0.375 $ 23,312,502.00 -9 3
SIL SMILES INCLUSIVE LTD 0.11 $ 6,995,397.50 -9 -65
TDL TBG DIAGNOSTICS LTD 0.031 $ 6,745,206.00 -9 -46
DXB DIMERIX LTD 0.1 $ 15,879,944.00 -9 12
BWX BWX LTD 2.13 $ 265,894,768.00 -9 35
RGS REGENEUS LTD 0.0929 $ 19,844,088.00 -10 -47
VHT VOLPARA HEALTH TECHNOLOGIES 1.5 $ 312,465,152.00 -10 32
CDY CELLMID LTD 0.22 $ 18,394,084.00 -10 -21
AVH AVITA MEDICAL LTD 0.395 $ 692,944,832.00 -11 357
SDI SDI LTD 0.77 $ 92,120,784.00 -11 22
M7T MACH7 TECHNOLOGIES LTD 0.685 $ 102,388,024.00 -11 226
CDX CARDIEX LTD 0.024 $ 16,692,053.00 -11 -17
ONE ONEVIEW HEALTHCARE PLC-CDI 0.24 $ 41,492,756.00 -11 -60
MXC MGC PHARMACEUTICALS LTD 0.05 $ 57,033,144.00 -11 18
OBJ OBJ LTD 0.015 $ 27,141,940.00 -12 -17
CAN CANN GROUP LTD 1.965 $ 275,100,224.00 -12 -5
TLX TELIX PHARMACEUTICALS LTD 1.39 $ 338,824,736.00 -12 109
ADR ADHERIUM LTD 0.022 $ 3,828,703.75 -12 -41
SKN SKIN ELEMENTS LTD 0.022 $ 3,574,204.00 -12 10
IDT IDT AUSTRALIA LTD 0.14 $ 33,173,442.00 -13 -3
RSH RESPIRI LTD 0.105 $ 58,787,724.00 -13 11
NC6 NANOLLOSE LTD 0.054 $ 4,049,999.50 -13 -39
KKT KONEKT LTD 0.23 $ 24,330,972.00 -13 -18
ANR ANATARA LIFESCIENCES LTD 0.29 $ 14,329,838.00 -13 -37
SVA SIMAVITA LTD-CDI 0.018 $ 7,520,006.50 -14 -5
PAR PARADIGM BIOPHARMACEUTICALS 1.46 $ 263,324,640.00 -14 34
PNV POLYNOVO LTD 1.485 $ 945,355,904.00 -15 140
1AD ADALTA LTD 0.175 $ 28,752,852.00 -15 -21
MMJ MMJ GROUP HOLDINGS LTD 0.27 $ 58,948,236.00 -15 11
MVP MEDICAL DEVELOPMENTS INTERNA 5.01 $ 328,894,080.00 -15 15
GSS GENETIC SIGNATURES LTD 1 $ 104,059,440.00 -15 25
GLH GLOBAL HEALTH LTD 0.16 $ 5,388,574.50 -16 23
THC THC GLOBAL GROUP LTD 0.46 $ 63,116,408.00 -16 0
EHH EAGLE HEALTH HOLDINGS LTD 0.26 $ 82,522,232.00 -16 62
RHY RHYTHM BIOSCIENCES LTD 0.175 $ 17,631,250.00 -17 25
GTG GENETIC TECHNOLOGIES LTD 0.005 $ 14,690,671.00 -17 -17
IPD IMPEDIMED LTD 0.125 $ 63,394,620.00 -17 -33
UCM USCOM LTD 0.105 $ 15,896,078.00 -18 -21
RNO RHINOMED LTD 0.295 $ 41,870,316.00 -18 55
S66 STAR COMBO PHARMA LTD 0.62 $ 52,787,328.00 -19 8
AGH ALTHEA GROUP HOLDINGS LTD 1.015 $ 197,210,704.00 -19 296
ADO ANTEO DIAGNOSTICS LTD 0.013 $ 17,931,688.00 -20 -26
PIQ PROTEOMICS INTERNATIONAL LAB 0.28 $ 22,592,350.00 -20 -26
CTE CRYOSITE LTD 0.04 $ 1,874,382.50 -20 -11
CMP COMPUMEDICS LTD 0.64 $ 113,384,288.00 -21 60
NSB NEUROSCIENTIFIC BIOPHARMACEU 0.24 $ 18,329,768.00 -22 81
EXL ELIXINOL GLOBAL LTD 2.98 $ 419,198,112.00 -22 22
BD1 BARD1 LIFE SCIENCES LTD 0.03 $ 38,281,180.00 -22 28
GMV G MEDICAL INNOVATION HOLDING 0.145 $ 57,725,656.00 -24 -46
JHL JAYEX HEALTHCARE LTD 0.044 $ 7,077,134.00 -25 116
ESE ESENSE-LAB LTD-CDI 0.022 $ 4,181,692.00 -27 -19
LBT LBT INNOVATIONS LTD 0.1 $ 22,357,280.00 -27 7
NXS NEXT SCIENCE LTD 2.78 $ 492,700,224.00 -27
NTI NEUROTECH INTERNATIONAL LTD 0.018 $ 2,307,645.75 -32 -57
RHT RESONANCE HEALTH LTD 0.09 $ 38,442,052.00 -33 50
ATX AMPLIA THERAPEUTICS LTD 0.087 $ 4,477,941.00 -44 -38