A one-day gain of 148 per cent has Opthea as comfortably the best-performing small cap health or biotech stock on the ASX at a time when the majority are trending downwards.

Stockhead reported today on Opthea’s (ASX:OPT) positive results from its Phase IIb trial of its OPT-302 drug, designed to fight wet age-related macular degeneration (AMD).

The company’s shares jumped to $1.90, a 148 per cent gain, though they hit as high as $2.25.

The trial examined whether OPT-302, when combined with Lucentis, a standard treatment for wet AMD, achieved a statistically significant vision benefit over patients receiving just Lucentis. It enrolled 366 patients over 24 weeks.

The results were conclusive: patients receiving OPT-302 gained a mean of 14.2 letters of vision from baseline on a standardised eye chart at 24 weeks, compared with 10.8 letters for the control group.

CEO Megan Baldwin told Stockhead the company would now design third-phase studies.

“We’re designing [Phase III] with the input of US regulators, but we can move forward knowing we have good solid data…and sufficient capital to be undertaking these activities,” she said.

The next-best performing health company in the past fortnight was Race Oncology (ASX:RAC), up 40 per cent on news the first leukaemia patient had been treated in its clinical trial of Bisantrene.

Bisantrene is a chemotherapy drug that was the subject of more than 40 clinical studies during the 1980s and 1990s before the drug was abandoned after a series of pharmaceutical mergers.

Overall, the ASX’s near-140 health and biotech stocks have lost 4 per cent in the past fortnight, with 89 stocks losing ground. Only 31 saw gains, while 15 were stable.

Here are the ASX’s near-140 small cap health and biotech stocks and their performance in the past fortnight:

Code Name Price (3pm Thursday) Market Cap % Return (2 Weeks) % Return YTD
PAA PHARMAUST LTD 0.14 $ 39,230,968.00 61 306
NEU NEUREN PHARMACEUTICALS LTD 2.18 $ 235,227,648.00 58 50
BWX BWX LTD 3.51 $ 441,087,104.00 51 -17
RAP RESAPP HEALTH LTD 0.22 $ 153,176,208.00 47 0
PNV POLYNOVO LTD 2.21 $ 1,500,669,824.00 45 298
RAC RACE ONCOLOGY LTD 0.12 $ 12,088,298.00 43 9
OPT OPTHEA LTD 3.74 $ 954,197,184.00 39 511
PSQ PACIFIC SMILES GROUP LTD 1.69 $ 256,868,832.00 35 22
AVE AVECHO BIOTECHNOLOGY LTD 0.006 $ 9,464,745.00 33 -67
SUD SUDA PHARMACEUTICALS LTD 0.004 $ 14,225,487.00 33 -16
PYC PHYLOGICA LTD 0.047 $ 114,814,264.00 31 57
ADR ADHERIUM LTD 0.026 $ 4,524,831.50 30 -71
PTX PRESCIENT THERAPEUTICS LTD 0.048 $ 19,713,032.00 22 -45
GTG GENETIC TECHNOLOGIES LTD 0.005 $ 17,628,804.00 20 -40
NHL NOVITA HEALTHCARE LTD 0.012 $ 7,282,618.00 20 -61
ATX AMPLIA THERAPEUTICS LTD 0.092 $ 4,735,294.00 19 -73
HCT HOLISTA COLLTECH LTD 0.068 $ 15,914,658.00 19 -23
PCK PAINCHEK LTD 0.2175 $ 201,114,160.00 19 349
ICS ICSGLOBAL LTD 1.085 $ 11,483,661.00 18 -2
DVL DORSAVI LTD 0.06 $ 12,241,007.00 18 -31
CGS COGSTATE LTD 0.23 $ 32,725,734.00 16 -66
MX1 MICRO-X LTD 0.34 $ 56,106,920.00 15 -3
CTE CRYOSITE LTD 0.057 $ 2,670,995.00 14 -11
OSL ONCOSIL MEDICAL LTD 0.073 $ 45,411,032.00 13 -67
NVL NATIONAL VETERINARY CARE LTD 2.53 $ 170,183,472.00 10 7
LBT LBT INNOVATIONS LTD 0.11 $ 25,887,376.00 10 0
ONE ONEVIEW HEALTHCARE PLC-CDI 0.225 $ 38,899,460.00 10 -81
VHT VOLPARA HEALTH TECHNOLOGIES 1.58 $ 344,538,720.00 9 68
PAR PARADIGM BIOPHARMACEUTICALS 1.6 $ 307,532,416.00 9 64
CDX CARDIEX LTD 0.026 $ 18,083,058.00 8 -40
FFC FARMAFORCE LTD 0.14 $ 17,892,138.00 8 40
KZA KAZIA THERAPEUTICS LTD 0.375 $ 23,312,502.00 7 -18
CAN CANN GROUP LTD 1.825 $ 259,501,776.00 7 -34
ALC ALCIDION GROUP LTD 0.165 $ 134,585,744.00 6 259
KKT KONEKT LTD 0.27 $ 28,562,446.00 6 -7
AVH AVITA MEDICAL LTD 0.4775 $ 861,527,040.00 6 360
AHX APIAM ANIMAL HEALTH LTD 0.47 $ 49,242,444.00 6 -14
SOM SOMNOMED LTD 2.11 $ 132,516,792.00 6 14
BIT BIOTRON LTD 0.078 $ 46,465,056.00 5 420
NC6 NANOLLOSE LTD 0.089 $ 6,674,999.50 5 -26
BOT BOTANIX PHARMACEUTICALS LTD 0.225 $ 217,013,488.00 5 127
LCT LIVING CELL TECHNOLOGIES LTD 0.023 $ 13,143,143.00 5 -23
PAB PATRYS LTD 0.023 $ 24,669,578.00 5 -47
JHC JAPARA HEALTHCARE LTD 1.105 $ 296,644,544.00 4 -35
1AD ADALTA LTD 0.13 $ 21,359,260.00 4 -57
IPD IMPEDIMED LTD 0.13 $ 68,479,688.00 4 -68
CMP COMPUMEDICS LTD 0.67 $ 121,356,616.00 3 41
GSS GENETIC SIGNATURES LTD 1.045 $ 111,863,896.00 2 99
OIL OPTISCAN IMAGING LTD 0.043 $ 20,217,688.00 2 -22
OVN OVENTUS MEDICAL LTD 0.505 $ 65,168,716.00 2 91
SDI SDI LTD 0.79 $ 93,903,768.00 2 36
THC THC GLOBAL GROUP LTD 0.445 $ 60,423,976.00 1 -14
MMJ MMJ GROUP HOLDINGS LTD 0.245 $ 55,547,376.00 0 -8
IVX INVION LTD 0.015 $ 82,509,096.00 0 -59
IMU IMUGENE LTD 0.02 $ 72,196,952.00 0 -9
UCM USCOM LTD 0.11 $ 15,204,944.00 0 -29
MEB MEDIBIO LTD 0.013 $ 12,936,691.00 0 -90
BXN BIOXYNE LTD 0.02 $ 12,802,908.00 0 -33
TDL TBG DIAGNOSTICS LTD 0.031 $ 6,745,206.00 0 -44
CDY CELLMID LTD 0.215 $ 17,976,038.00 0 -43
ZLD ZELDA THERAPEUTICS LTD 0.068 $ 50,741,908.00 0 -16
BPH BPH ENERGY LTD 0.002 $ 2,990,277.75 0 33
RHT RESONANCE HEALTH LTD 0.11 $ 49,120,404.00 0 379
CAJ CAPITOL HEALTH LTD 0.215 $ 169,057,856.00 0 -21
S66 STAR COMBO PHARMA LTD 0.52 $ 44,999,032.00 0 -40
BNO BIONOMICS LTD 0.037 $ 20,153,378.00 0 -92
DXB DIMERIX LTD 0.095 $ 15,085,947.00 0 -5
RCE RECCE PHARMACEUTICALS LTD 0.215 $ 23,032,932.00 0 19
VBS VECTUS BIOSYSTEMS LTD 0.55 $ 12,858,998.00 0 -42
OCC ORTHOCELL LTD 0.45 $ 60,950,844.00 -1 32
LSH LIFESPOT HEALTH LTD 0.062 $ 4,886,826.50 -2 -28
BLT BENITEC BIOPHARMA LTD 0.052 $ 13,365,530.00 -2 -72
NSB NEUROSCIENTIFIC BIOPHARMACEU 0.245 $ 18,392,436.00 -2 21
IMM IMMUTEP LTD 0.022 $ 81,191,120.00 -2 -41
CYP CYNATA THERAPEUTICS LTD 1.64 $ 163,736,080.00 -2 14
ONT 1300 SMILES LTD 6 $ 142,070,304.00 -2 1
AZV AZURE HEALTHCARE LTD 0.078 $ 18,151,600.00 -3 -3
PBP PROBIOTEC LTD 1.53 $ 91,844,168.00 -3 -4
PXS PHARMAXIS LTD 0.185 $ 72,992,712.00 -3 -40
CYC CYCLOPHARM LTD 1.35 $ 93,013,480.00 -3 53
JHL JAYEX HEALTHCARE LTD 0.033 $ 5,696,230.00 -3 -6
TLX TELIX PHARMACEUTICALS LTD 1.28 $ 330,141,472.00 -3 42
MVP MEDICAL DEVELOPMENTS INTERNA 4.65 $ 300,721,856.00 -3 12
BD1 BARD1 LIFE SCIENCES LTD 0.029 $ 39,648,364.00 -3 130
ATH ALTERITY THERAPEUTICS LTD 0.03 $ 24,326,386.00 -3 -36
IDT IDT AUSTRALIA LTD 0.14 $ 33,173,442.00 -3 -7
ELX ELLEX MEDICAL LASERS LTD 0.565 $ 80,416,616.00 -3 -27
HLA HEALTHIA LTD 0.92 $ 57,991,884.00 -4
NXS NEXT SCIENCE LTD 2.75 $ 490,915,072.00 -4
ANP ANTISENSE THERAPEUTICS LTD 0.049 $ 20,585,070.00 -4 133
MDR MEDADVISOR LTD 0.048 $ 65,922,356.00 -4 14
ESE ESENSE-LAB LTD-CDI 0.022 $ 4,181,692.00 -4 -64
ANR ANATARA LIFESCIENCES LTD 0.195 $ 10,870,912.00 -4 -61
SKN SKIN ELEMENTS LTD 0.021 $ 3,411,740.25 -5 -19
IMC IMMURON LTD 0.13 $ 18,561,996.00 -5 -69
UBI UNIVERSAL BIOSENSORS INC-CDI 0.1975 $ 34,583,084.00 -5 -15
NOX NOXOPHARM LTD 0.37 $ 47,933,940.00 -5 -40
PAL PALLA PHARMA LTD 1.07 $ 86,761,584.00 -5 -33
AGH ALTHEA GROUP HOLDINGS LTD 0.785 $ 179,487,008.00 -6
RHY RHYTHM BIOSCIENCES LTD 0.17 $ 17,127,500.00 -6 21
OBJ OBJ LTD 0.016 $ 28,951,402.00 -6 -33
ACW ACTINOGEN MEDICAL LTD 0.008 $ 8,953,851.00 -6 -86
CPH CRESO PHARMA LTD 0.39 $ 59,860,012.00 -6 -35
SCU STEMCELL UNITED LTD 0.016 $ 9,624,125.00 -6 -35
VLS VITA LIFE SCIENCES LTD 0.65 $ 36,259,804.00 -6 5
ADO ANTEO DIAGNOSTICS LTD 0.013 $ 19,425,996.00 -7 5
PIQ PROTEOMICS INTERNATIONAL LAB 0.25 $ 20,171,742.00 -7 2
AC8 AUSCANN GROUP HOLDINGS LTD 0.37 $ 115,722,288.00 -8 -62
ACR ACRUX LTD 0.175 $ 29,178,224.00 -8 -19
AMT ALLEGRA ORTHOPAEDICS LTD 0.11 $ 10,951,496.00 -8 22
M7T MACH7 TECHNOLOGIES LTD 0.685 $ 105,189,744.00 -9 233
MEM MEMPHASYS LTD 0.047 $ 29,153,096.00 -10 241
RGS REGENEUS LTD 0.071 $ 19,055,486.00 -10 -62
PGC PARAGON CARE LTD 0.385 $ 131,775,264.00 -10 -44
RSH RESPIRI LTD 0.085 $ 47,505,064.00 -11 6
MDC MEDLAB CLINICAL LTD 0.445 $ 95,837,280.00 -11 -11
IBX IMAGION BIOSYSTEMS LTD 0.039 $ 12,948,213.00 -11 -49
CP1 CANNPAL ANIMAL THERAPEUTICS 0.155 $ 14,900,000.00 -11 -11
FTT FACTOR THERAPEUTICS LTD 0.0035 $ 3,649,924.75 -13 -93
EXL ELIXINOL GLOBAL LTD 2.15 $ 301,988,096.00 -13 46
IHL IMPRESSION HEALTHCARE LTD 0.076 $ 44,947,044.00 -15 310
VTI VISIONEERING TECH-CDI 0.045 $ 17,961,082.00 -17 -74
GLH GLOBAL HEALTH LTD 0.125 $ 4,209,824.00 -17 -38
NTI NEUROTECH INTERNATIONAL LTD 0.014 $ 1,900,414.13 -18 -88
MXC MGC PHARMACEUTICALS LTD 0.04 $ 54,288,844.00 -20 -27
RNO RHINOMED LTD 0.25 $ 35,483,320.00 -22 14
ALT ANALYTICA LTD 0.004 $ 10,558,837.00 -25 -50
OSP OSPREY MEDICAL INC-CDI 0.046 $ 19,862,680.00 -26 -78
SIL SMILES INCLUSIVE LTD 0.072 $ 4,796,844.00 -28 -93
SDX SIENNA CANCER DIAGNOSTICS LT 0.035 $ 10,116,931.00 -29 -58
1ST 1ST GROUP LTD 0.055 $ 19,546,238.00 -29 62
MVF MONASH IVF GROUP LTD 1.02 $ 238,143,744.00 -30 -13
SVA SIMAVITA LTD-CDI 0.01 $ 2,924,447.00 -30 -80
GMV G MEDICAL INNOVATION HOLDING 0.08 $ 32,293,214.00 -33 -76
EHH EAGLE HEALTH HOLDINGS LTD 0.155 $ 40,452,076.00 -46 -58