• Biotech could be a US$4 trillion industry in 10 years
  • Genetic engineering and weight loss are two growing themes in the space
  • We look at the best and worst performing ASX biotechs over the past month

 

Steve Jobs used to say that the most significant advancements of the 21st century would arise from the convergence of biology and technology.

He’s not far off the mark as the global biotech market is poised to triple to USD 3,995.22 billion (that’s $4 trillion) by 2032 – according to data from Precedence Research.

The market is witnessing unprecedented growth due to the increasing demand for food, prevalence of chronic diseases, and advancements in technology.

The research suggests that DNA sequencing and genetic engineering technology would be one area to see increasing investments over the next few years. This is a segment of biotech where drugs are developed using living cells, designed to target specific proteins, cells, and genetic pathways.

These drugs target a wide range of diseases, including cancer, autoimmune disorders, and infectious diseases. They’ve also been used to treat rare genetic disorders, such as cystic fibrosis and hemophilia.

Another example of genetic engineering is the use of DNA technology to produce insulin for the treatment of diabetes.

Recombinant DNA technology involves inserting a human gene for insulin production into a bacterial or yeast cell. This method has revolutionised the treatment of diabetes and has made insulin more widely available and affordable.

Ark fund manager Cathie Wood has been a strong believer in genetic technologies, and her portfolio reflects her conviction.

In a filing last week, Wood added to the Ark fund 6 million more shares of genetics biotech firm, Ginkgo Bioworks, a company that’s been a favourite of hers for a while now. Ginkgo has ongoing programs in cell engineering and enzymes, amongst others.

 

Weight loss is another growing theme

Another segment of biotech that could see huge demand going forward is obesity drugs.

According to Morgan Stanley, the recent frenzy around Ozempic and Wegovy could see the weight-loss drugs sector surge to US$77 billion by 2030.

Ozempic and Wegovy work by mimicking the effects of GLP-1, a gut hormone that can help control blood-sugar levels and reduce appetite. (GLP stands for glucagon-like peptide.)

A recent survey in the US shows that nearly half of adults want to lose weight, and would be interested in taking a prescription drug to help them do so.

An estimated 42% of the American population meanwhile is classified as obese.

 

Best and worst performing ASX biotechs over the past month

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CODE COMPANY PRICE 1 WEEK RETURN % 1 MONTH RETURN % 6 MONTH RETURN % 1 YEAR RETURN % MARKET CAP
BDX Bcaldiagnostics 0.15 3.45 114.29 141.94 76.47 $29,852,577
1ST 1St Group Ltd 0.01 0.00 80.00 0.00 -10.00 $12,752,921
AVE Avecho Biotech Ltd 0.01 25.00 50.00 -28.57 -46.43 $15,135,146
LDX Lumos Diagnostics 0.09 70.59 35.94 155.88 26.09 $31,484,446
BOT Botanix Pharma Ltd 0.19 18.75 35.71 183.58 137.50 $248,709,442
ADR Adherium Ltd 0.00 0.00 33.33 0.00 -60.00 $24,997,042
AN1 Anagenics Limited 0.02 5.26 33.33 -10.27 -38.82 $6,581,159
RHT Resonance Health 0.07 14.04 30.00 10.17 -16.67 $29,955,379
DOC Doctor Care Anywhere 0.06 -5.00 26.67 -8.06 -79.27 $20,898,608
ATH Alterity Therap Ltd 0.01 14.29 23.08 -5.88 -46.67 $17,079,283
EZZ EZZ Life Science 0.62 -9.56 23.00 78.26 73.24 $26,904,150
RNO Rhinomed Ltd 0.08 7.14 20.97 -16.67 -55.88 $21,428,977
GLH Global Health Ltd 0.15 0.00 20.00 -16.67 -57.14 $8,707,430
SHG Singular Health 0.05 28.95 16.67 -53.33 -71.18 $5,511,100
HGV Hygrovest Limited 0.05 2.17 14.63 -32.86 -28.79 $9,884,598
IPD Impedimed Limited 0.20 -2.44 14.29 233.33 166.67 $393,662,404
ALC Alcidion Group Ltd 0.11 -2.17 12.50 -19.64 -29.69 $145,827,941
ONE Oneview Healthcare 0.23 0.00 12.20 100.00 43.75 $154,808,587
ZNO Zoono Group Ltd 0.05 -8.00 12.20 -49.97 -67.91 $8,736,673
CYP Cynata Therapeutics 0.15 0.00 11.54 -52.46 -65.48 $26,046,609
IRX Inhalerx Limited 0.04 0.00 11.43 -35.00 -50.00 $7,400,911
KZA Kazia Therapeutics 0.15 0.00 11.11 25.00 -40.00 $35,452,406
S66 Star Combo 0.11 -6.38 10.00 -37.14 -54.17 $14,859,128
RCE Recce Pharmaceutical 0.72 2.86 9.92 27.43 -22.16 $122,995,474
AMT Allegra Orthopaedics 0.06 0.00 9.09 -14.29 -64.71 $6,267,552
CDX Cardiex Limited 0.18 9.09 9.09 -38.98 -47.83 $23,707,781
NXS Next Science Limited 0.60 0.00 9.09 -17.81 -37.50 $133,169,883
PNV Polynovo Limited 1.71 11.97 7.73 -24.45 -20.21 $1,149,237,530
PCK Painchek Ltd 0.03 -9.38 7.41 3.57 -3.33 $36,992,702
UBI Universal Biosensors 0.27 -1.85 6.00 -18.46 -11.67 $58,401,595
CYC Cyclopharm Limited 2.30 -1.29 5.99 47.91 58.62 $219,483,403
4DX 4Dmedical Limited 0.72 19.17 5.93 78.75 5.15 $239,867,138
BPH BPH Energy Ltd 0.02 0.00 5.26 11.11 27.36 $18,604,710
SDI SDI Limited 0.86 -1.15 4.88 -7.53 1.18 $101,630,028
CHM Chimeric Therapeutic 0.04 18.92 4.76 -40.54 -68.57 $20,117,312
CU6 Clarity Pharma 0.96 8.47 4.35 15.66 50.00 $178,538,613
CAN Cann Group Ltd 0.13 4.17 4.17 -31.89 -55.79 $53,160,496
OPT Opthea Limited 0.62 10.71 2.48 -31.11 -50.79 $261,609,283
MDR Medadvisor Limited 0.23 9.52 2.22 -9.80 43.75 $122,876,727
ACR Acrux Limited 0.05 2.13 2.13 -21.31 -23.81 $13,256,071
IMC Immuron Limited 0.08 6.76 1.28 1.28 -13.19 $17,996,069
ALT Analytica Limited 0.00 0.00 0.00 0.00 -33.33 $4,613,801
TSN The Sust Nutri Grp 0.01 0.00 0.00 -44.44 -92.86 $1,409,029
MEB Medibio Limited 0.00 -33.33 0.00 -33.33 0.00 $5,150,594
AHC Austco Healthcare 0.17 0.00 0.00 47.83 41.67 $49,434,328
AC8 Auscann Grp Hlgs Ltd 0.04 0.00 0.00 0.00 -14.89 $17,621,884
BWX BWX Limited 0.20 0.00 0.00 -11.11 -72.97 $39,997,500
CTE Cryosite Limited 0.65 0.00 0.00 -16.67 -2.26 $31,726,216
MX1 Micro-X Limited 0.11 10.00 0.00 -18.52 -26.67 $56,806,749
MEM Memphasys Ltd 0.02 6.25 0.00 13.33 -60.40 $14,392,806
TD1 Tali Digital Limited 0.00 0.00 0.00 -60.00 -80.00 $3,295,156
NTI Neurotech Intl 0.04 -4.35 0.00 -20.00 -60.00 $38,452,017
MDC Medlab Clinical Ltd 6.60 0.00 0.00 -5.04 -43.15 $15,071,113
NOX Noxopharm Limited 0.04 5.88 0.00 -65.71 -85.31 $10,228,328
ARX Aroa Biosurgery 0.90 1.69 0.00 -17.81 6.51 $305,367,427
ALA Arovella Therapeutic 0.05 -2.08 0.00 38.24 74.07 $40,487,166
IDT IDT Australia Ltd 0.07 -1.49 0.00 -7.04 -54.48 $23,188,252
OCC Orthocell Limited 0.39 0.00 -1.28 1.32 -4.94 $75,961,682
DXB Dimerix Ltd 0.07 2.86 -1.37 -43.63 -54.20 $28,420,016
MVF Monash IVF Group Ltd 1.18 -0.84 -1.67 7.80 12.44 $459,769,111
AT1 Atomo Diagnostics 0.04 16.67 -2.78 -30.00 -54.55 $20,454,474
ZLD Zelira Therapeutics 1.50 -7.41 -3.23 25.00 -16.67 $17,020,733
ZLD Zelira Therapeutics 1.50 -7.41 -3.23 25.00 -16.67 $17,020,733
NC6 Nanollose Limited 0.06 -8.33 -3.51 -14.06 -24.66 $8,188,750
LBT LBT Innovations 0.03 23.81 -3.70 -57.72 -63.89 $9,100,161
TRU Truscreen 0.03 -3.85 -3.85 -13.79 -44.44 $10,832,692
EYE Nova EYE Medical Ltd 0.25 -5.77 -3.92 -9.26 0.00 $47,627,473
PBP Probiotec Limited 2.57 0.78 -5.17 12.72 12.72 $209,001,153
VLS Vita Life Sciences.. 1.48 -1.33 -5.43 -2.63 -28.50 $80,931,918
CAJ Capitol Health 0.24 4.35 -5.88 -14.29 -26.15 $260,563,022
BIT Biotron Limited 0.03 14.29 -5.88 14.29 -44.00 $27,058,347
ATX Amplia Therapeutics 0.08 -4.82 -5.95 -12.22 -20.20 $16,102,480
IMU Imugene Limited 0.09 2.17 -6.00 -27.69 -67.59 $603,765,676
LCT Living Cell Tech. 0.02 0.00 -6.25 68.74 51.87 $24,527,185
VBS Vectus Biosystems 0.40 -11.11 -6.98 -43.66 -55.56 $21,275,808
OSX Osteopore Limited 0.07 -5.26 -7.10 -39.33 -67.64 $11,618,897
DVL Dorsavi Ltd 0.01 8.33 -7.14 -7.14 8.33 $7,236,601
ICR Intelicare Holdings 0.01 0.00 -7.69 -47.83 -66.59 $2,506,985
IMM Immutep Ltd 0.30 -1.67 -7.81 17.51 -9.20 $356,191,863
1AD Adalta Limited 0.02 0.00 -8.00 -39.47 -58.93 $10,155,105
CBL Control Bionics 0.08 -1.27 -8.24 -51.25 -61.95 $8,192,713
VTI Vision Tech Inc 0.22 4.76 -8.33 -37.14 -37.14 $6,977,788
GSS Genetic Signatures 0.55 -0.91 -8.40 -36.63 -45.50 $81,024,388
NEU Neuren Pharmaceut. 12.42 3.07 -8.61 69.90 127.06 $1,603,587,115
PAA Pharmaust Limited 0.07 -2.67 -8.75 -14.12 -9.88 $25,460,571
RSH Respiri Limited 0.03 -28.57 -9.09 -35.48 -34.78 $30,828,726
SOM SomnoMed Limited 0.94 3.87 -9.62 -23.58 -23.89 $76,138,570
JTL Jayex Technology Ltd 0.01 0.00 -10.00 -18.18 50.00 $2,531,507
AGH Althea Group 0.04 -4.55 -10.64 -19.23 -67.69 $16,647,113
CMP Compumedics Limited 0.17 0.00 -10.81 -8.33 -29.79 $29,231,886
TRP Tissue Repair 0.28 -1.79 -11.29 5.77 -17.91 $12,864,598
OIL Optiscan Imaging 0.08 -2.53 -12.50 -21.42 -34.52 $64,298,142
PGC Paragon Care Limited 0.23 2.27 -13.46 -28.57 -35.71 $145,056,104
PSQ Pacific Smiles Grp 1.33 -3.28 -13.96 -7.02 -17.96 $211,446,068
EXL Elixinol Wellness 0.01 -7.69 -14.29 -55.56 -71.43 $5,483,896
NSB Neuroscientific 0.09 3.45 -14.29 -3.23 -65.38 $12,580,624
CGS Cogstate Ltd 1.40 -3.45 -14.63 -37.78 -24.32 $246,790,259
IBX Imagion Biosys Ltd 0.02 13.33 -15.00 -32.00 -56.41 $20,892,265
PAR Paradigm Bio. 0.85 -0.59 -15.08 -44.77 -40.48 $242,050,031
PIQ Proteomics Int Lab 0.73 -8.75 -15.12 -30.14 -23.96 $88,692,673
M7T Mach7 Tech Limited 0.78 -5.49 -15.30 4.73 11.51 $186,007,270
HCT Holista CollTech Ltd 0.01 0.00 -15.38 -38.89 -71.05 $3,066,801
OSL Oncosil Medical 0.01 0.00 -15.38 -63.41 -76.66 $21,734,252
EPN Epsilon Healthcare 0.02 -12.50 -16.00 -16.00 -40.00 $6,307,434
TLX Telix Pharmaceutical 9.94 -4.29 -16.16 63.94 29.70 $3,245,468,168
HXL Hexima 0.02 -13.04 -16.67 17.65 60.00 $3,841,911
BP8 Bph Global Ltd 0.00 25.00 -16.67 -81.01 -81.01 $3,336,824
RHY Rhythm Biosciences 0.43 1.19 -16.67 -55.26 -70.69 $94,994,563
PXS Pharmaxis Ltd 0.05 -10.00 -18.18 -19.64 -40.00 $31,701,432
PTX Prescient Ltd 0.07 -2.90 -19.28 -39.09 -63.78 $55,563,616
RGS Regeneus Ltd 0.01 -20.00 -20.00 -33.33 -85.19 $2,451,495
ANP Antisense Therapeut. 0.05 -1.89 -20.00 -44.09 -52.73 $43,487,858
RAD Radiopharm 0.09 -5.43 -20.91 -35.56 -59.09 $21,298,860
RAD Radiopharm 0.09 -5.43 -20.91 -35.56 -59.09 $21,298,860
PYC PYC Therapeutics 0.06 -1.79 -21.43 -20.29 -20.29 $209,040,560
IIQ Inoviq Ltd 0.69 -9.21 -21.59 18.97 8.66 $63,492,904
IHL Incannex Healthcare 0.09 8.05 -21.67 -41.25 -65.19 $152,352,994
ME1 Melodiol Glb Health 0.01 -12.50 -22.22 -61.11 -82.05 $17,338,494
ILA Island Pharma 0.09 -5.56 -22.73 -29.17 -55.26 $6,907,820
NYR Nyrada Inc. 0.03 -3.33 -23.68 -76.80 -82.42 $4,524,252
VHT Volpara Health Tech 0.74 -7.19 -24.62 -7.19 6.07 $194,584,106
BXN Bioxyne Ltd 0.02 -16.67 -25.00 -46.43 15.38 $28,524,681
PAB Patrys Limited 0.01 0.00 -25.00 -67.86 -66.67 $18,517,026
ADO Anteotech Ltd 0.03 0.00 -26.83 -37.50 -60.53 $63,073,217
ACW Actinogen Medical 0.03 -17.97 -26.84 -68.89 -67.77 $47,222,556
GTG Genetic Technologies 0.00 0.00 -33.33 -42.86 -60.00 $23,083,316
MVP Medical Developments 0.98 -0.51 -34.34 -25.29 -50.76 $85,442,167
IVX Invion Ltd 0.01 -16.67 -37.50 -33.33 -54.55 $35,318,977
AHK Ark Mines Limited 0.22 -12.24 -40.28 22.86 -21.82 $10,383,294
BNO Bionomics Limited 0.01 -4.17 -45.24 -64.06 -77.88 $16,156,090
RAC Race Oncology Ltd 0.86 -25.22 -46.08 -57.00 -56.78 $147,577,246
MXC Mgc Pharmaceuticals 0.00 0.00 -50.00 -80.00 -88.89 $7,784,719
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BCAL Diagnostics (ASX:BDX)

BCAL was the best biotech performer over the past month after announcing breakthrough results from its Precion clinical study in the US.

Results showed that BCAL’s breast cancer diagnostic test achieved an impressive sensitivity of 90%, and a specificity of 85.5%. These results were consistent with the findings of earlier studies conducted in Australia using a different mass spectrometry platform.

BCAL says the replication of these results is a major breakthrough in the path to commercialisation of the BCAL test, with sales expected to commence in the second half of calendar 2024.

 

Lumos Diagnostics (ASX:LDX)

Lumos surged after announcing that a core patent covering the camera technology used in its reader platform has been granted for Europe and Japan.

The patent, called “Device for reading an IVD assay”, covers the use of Lumos’ proprietary camera technology which is incorporated in many of its readers.

These readers have become a critical component of new point-of-care tests as they automate the reading and quantification of results, which in turn allows them to be seamlessly integrated into electronic medical record systems.

The latest patent covers the use of Lumos’ reader technology in the European and Japanese markets until 2036. The technology has already been granted in the United States and Australia.

 

Adherium (ASX:ADR)

Adherium rose after signing a collaboration agreement with US-based Allergy Partners for asthma management to serve its more than 300,000 patients across 130 sites in 20 states.

Adherium’s Hailie provides real-time data for patient feedback for self-management, and enables doctors to bill remote patients to generate repeat, multi-year revenues.

Initial roll out is for three states, with new employee training starting this month and expansion to more states to follow this calendar year.

 

Alterity Therapeutics (ASX:ATH)

The neurodegenerative diseases specialist received a $4.74 million cash refund from the Australian Taxation Office for its R&D activities.

The company says the funds will be used to further Alterity’s clinical research activities, including the ongoing Phase 2 clinical trials for its lead drug candidate ATH434 in Multiple System Atrophy (MSA), a Parkinsonian disorder with no approved therapy.

 

Rhinomed (ASX:RNO)

The wearable nasal and respiratory technology company has received a Notice of Allowance from the US Patent Office relating to the company’s Mute nasal dilator technology.

This application was filed in December 2016, and the approval will now provide further protection to Rhinomed’s family of medical devices which deliver improved sleep, less snoring and better breathing during sleep and aerobic activity.

In the US, Mute is currently sold through leading drug store and grocery chains including Walgreens, CVS, Rite Aid, Ingles Markets and online through Amazon.