It’s been a mixed two weeks for small-cap health companies, with 60 companies gaining ground and 52 losing it – and 21 flatlining.

Botanix Pharma Ltd (ASX:BOT) was the biggest gainer, up 38% from 23 June to 7 July, and Suda Pharmaceuticals (ASX:SUD) was up 36% – but both on no news.

The next cab off the ranks was Medibio Limited (ASX:MEB) rising 29% off the back of a newsletter to shareholders detailing the company’s plans to launch its consumer app in October.

CEO and managing director Claude Solitario said the algorithm development for its depressive burden software, MEB-001 and the corporate mental wellness offering ilumen are both “progressing very well.”

The company is also waiting for an FDA meeting about MEBSleep to clear the path for a 60-70 patient, multi-centre pivotal validation trial.

Both up 25% were Chimeric Therapeutics (ASX:CHM) after appointing Dr George Matcham as non-executive director, and Atomo Diagnostics (ASX:AT1) on the news that Access Bio received FDA clearance for its COVID-19 antibody test late last month.

Alterity Theraputics (ASX:ATH) was up 24% after announcing the grant of a new US patent targeting major neurodegenerative diseases including Alzheimer’s and Parkinson’s, and gaining 23% was Pharmaxis (ASX:PXS) – which sold distribution rights in Australia, New Zealand (and several Asian territories) for its Bronchitol® (cystic fibrosis) and Aridol® (asthma) products to a subsidiary of BTC health (ASX:BTC).

Here’s a table showing how ASX-listed healthcare stocks have been performing.

Code Company Price %Yr %2WK MktCap
BOT Botanix Pharma Ltd 0.088 100 38 $ 84,663,360.44
SUD Suda Pharmaceuticals 0.068 123 36 $ 33,657,399.02
MEB Medibio Limited 0.009 29 29 $ 16,155,553.48
CHM Chimeric Therapeutic 0.345 73 25 $ 68,891,660.25
AT1 Atomo Diagnostics 0.1875 -47 25 $ 79,694,615.72
ATH Alterity Therap Ltd 0.036 -14 24 $ 86,647,484.81
TD1 Tali Digital Limited 0.038 46 23 $ 35,412,419.98
PXS Pharmaxis Ltd 0.087 16 23 $ 39,395,702.27
ANP Antisense Therapeut. 0.22 165 22 $ 132,129,558.89
BIT Biotron Limited 0.061 -53 22 $ 41,414,030.07
ARX Aroa Biosurgery 1.23 64 20 $ 368,818,235.98
UBI Universal Biosensors 0.935 356 20 $ 162,572,030.25
NYR Nyrada Inc. 0.34 45 19 $ 40,557,939.51
VTI Vision Tech, Inc 1.28 -33 19 $ 31,080,682.50
CGS Cogstate Ltd 1.4 229 17 $ 239,383,663.40
NEU Neuren Pharmaceut. 1.595 18 16 $ 183,372,972.80
DVL Dorsavi Ltd 0.03 1 15 $ 10,878,909.73
RHT Resonance Health 0.17 3 13 $ 82,953,356.58
SCU Stemcell United Ltd 0.017 13 13 $ 17,736,451.19
AVE Avecho Biotech Ltd 0.018 157 13 $ 33,050,097.47
GTG Genetic Technologies 0.009 38 13 $ 81,150,540.69
AHC Austco Healthcare 0.14 77 12 $ 38,365,508.39
PTX Prescient Ltd 0.25 291 11 $ 160,263,264.00
EYE Nova EYE Medical Ltd 0.32 -12 10 $ 47,416,425.54
CBL Control Bionics 0.66 10 10 $ 33,646,660.99
GSS Genetic Signatures 1.285 -49 9 $ 178,634,057.50
OSL Oncosil Medical 0.065 -50 8 $ 51,029,970.82
OVN Oventus Medical Ltd 0.105 -64 8 $ 23,689,200.43
VHT Volpara Health Tech 1.19 -20 8 $ 296,551,795.58
MMJ MMJ Group Hlds Ltd 0.084 -15 8 $ 19,086,180.76
IVX Invion Ltd 0.015 50 7 $ 83,093,134.43
OSP Osprey Med Inc 0.015 -66 7 $ 35,920,923.89
ZLD Zelira Therapeutics 0.048 -14 7 $ 57,135,502.37
CAN Cann Group Ltd 0.41 -56 6 $ 113,943,919.18
HXL Hexima 0.165 -46 6 $ 21,065,171.58
MX1 Micro-X Limited 0.34 152 6 $ 158,597,100.30
SOM SomnoMed Limited 2.44 82 6 $ 201,105,135.45
ADR Adherium Ltd 0.018 -33 6 $ 34,011,729.78
CAJ Capitol Health 0.365 49 6 $ 385,536,567.00
BD1 Bard1 Life Sciences 1.915 113 6 $ 148,104,922.75
OPT Opthea Limited 1.35 -46 5 $ 491,404,957.40
4DX 4Dmedical Limited 1.315 78 5 $ 265,240,970.24
IPD Impedimed Limited 0.105 38 5 $ 164,339,614.89
RAP Resapp Health Ltd 0.044 -73 5 $ 36,945,474.31
OSX Osteopore Limited 0.475 -27 4 $ 37,067,955.00
PAB Patrys Limited 0.052 336 4 $ 90,979,845.25
APH AP Hemp Ltd 0.405 238 4 $ 32,092,256.70
BXN Bioxyne Ltd 0.028 155 4 $ 17,924,071.14
TLX Telix Pharmaceutical 5.69 272 3 $ 1,560,193,680.32
MDR Medadvisor Limited 0.305 -47 3 $ 113,211,191.70
TRU Truscreen 0.068 0 3 $ 23,586,306.45
PIQ Proteomics Int Lab 0.975 132 3 $ 105,205,875.00
AC8 Auscann Grp Hlgs Ltd 0.1075 -28 2 $ 48,460,182.10
DOC Doctor Care Anywhere 0.88 10 2 $ 157,699,453.12
PAA Pharmaust Limited 0.091 -60 2 $ 28,822,422.72
EPN Epsilon Healthcare 0.1325 -56 2 $ 25,051,903.37
KZA Kazia Therapeutics 1.325 163 2 $ 178,282,721.11
NTI Neurotech Intl 0.056 409 2 $ 39,021,871.06
AGH Althea Group 0.34 -1 1 $ 90,518,871.30
M7T Mach7 Tech Limited 1.03 8 1 $ 233,977,639.50
JHC Japara Healthcare Lt 1.2475 147 0 $ 334,059,160.00
ONT 1300 Smiles Limited 7.1 39 0 $ 168,116,526.40
1ST 1St Group Ltd 0.021 -38 0 $ 8,916,954.96
ACR Acrux Limited 0.14 -7 0 $ 39,662,755.16
ATX Amplia Therapeutics 0.225 105 0 $ 28,084,801.50
ALT Analytica Limited 0.0025 0 0 $ 11,534,502.82
AHK Ark Mines Limited 0.034 0 0 $ 1,778,919.95
CDY Cellmid Limited 0.06 -54 0 $ 11,245,833.60
CMP Compumedics Limited 0.4 0 0 $ 72,636,808.68
DXB Dimerix Ltd 0.22 -41 0 $ 42,569,848.86
EXL Elixinol Wellness 0.13 -30 0 $ 40,958,210.02
ICS ICSGlobal Limited 2.19 12 0 $ 23,047,601.61
IMC Immuron Limited 0.16 -37 0 $ 36,359,455.36
LCT Living Cell Tech. 0.014 -7 0 $ 8,000,173.73
MDC Medlab Clinical Ltd 0.16 7 0 $ 54,748,107.36
MXC Mgc Pharmaceuticals 0.04 82 0 $ 94,737,878.93
PSQ Pacific Smiles Grp 2.74 77 0 $ 438,850,329.50
PCK Painchek Ltd 0.061 -49 0 $ 66,481,483.14
PGC Paragon Care Limited 0.275 49 0 $ 91,229,028.84
RGS Regeneus Ltd 0.075 -4 0 $ 23,068,915.59
PAR Paradigm Bio. 2.03 -40 0 $ 459,979,319.94
MVF Monash IVF Group Ltd 0.82 38 -1 $ 331,189,614.00
IMU Imugene Limited 0.3375 864 -1 $ 1,662,551,924.95
NOX Noxopharm Limited 0.67 219 -1 $ 198,872,991.63
VLS Vita Life Sciences.. 1.11 102 -1 $ 58,444,399.32
EZZ EZZ Life Science 0.46 -8 -1 $ 5,520,000.00
ADO Anteotech Ltd 0.26 1138 -2 $ 497,925,453.18
S66 Star Combo 0.25 -35 -2 $ 33,678,117.25
IHL Incannex Healthcare 0.245 308 -2 $ 265,083,190.00
ZNO Zoono Group Ltd 0.645 -80 -2 $ 102,137,378.34
LBT LBT Innovations 0.081 -57 -2 $ 25,442,134.43
BNO Bionomics Limited 0.195 273 -3 $ 196,481,365.08
CTE Cryosite Limited 0.39 200 -3 $ 18,275,229.57
CDX Cardiex Limited 0.073 170 -3 $ 71,304,937.94
GLH Global Health Ltd 0.51 143 -3 $ 25,259,323.35
RCE Recce Pharmaceutical 0.92 35 -3 $ 167,695,622.36
NXS Next Science Limited 1.505 -3 -3 $ 312,798,776.22
RNO Rhinomed Ltd 0.15 100 -3 $ 38,071,369.80
RAC Race Oncology Ltd 3.58 348 -3 $ 517,143,034.80
CPH Creso Pharma Ltd 0.14 338 -3 $ 143,275,059.20
1AD Adalta Limited 0.135 14 -4 $ 34,325,140.92
RSH Respiri Limited 0.072 -28 -4 $ 51,321,696.09
FFC Farmaforce Ltd 0.067 22 -4 $ 8,755,625.66
IDT IDT Australia Ltd 0.31 72 -5 $ 74,356,652.70
SHG Singular Health 0.3 50 -5 $ 18,574,729.42
IBX Imagion Biosys Ltd 0.095 111 -5 $ 98,010,503.33
PAL Palla Pharma Ltd 0.38 -47 -5 $ 64,765,265.20
ICR Intelicare Holdings 0.18 -51 -5 $ 8,685,866.74
MVP Medical Developments 4.44 -38 -5 $ 319,265,730.56
IMM Immutep Ltd 0.53 221 -5 $ 407,743,349.58
SDI SDI Limited 0.88 27 -5 $ 105,790,321.70
RHY Rhythm Biosciences 0.865 941 -6 $ 181,953,729.90
BPH BPH Energy Ltd 0.075 380 -6 $ 48,539,115.40
ILA Island Pharma 0.3 20 -6 $ 12,238,802.31
OIL Optiscan Imaging 0.225 463 -6 $ 132,496,029.43
CYP Cynata Therapeutics 0.52 -17 -6 $ 74,503,828.88
NC6 Nanollose Limited 0.089 117 -6 $ 13,381,773.12
PBP Probiotec Limited 2.04 3 -6 $ 160,065,348.24
OCC Orthocell Limited 0.57 65 -7 $ 104,821,283.05
JTL Jayex Technology Ltd 0.028 12 -7 $ 5,952,252.03
BWX BWX Limited 4.87 30 -7 $ 695,106,774.45
VBS Vectus Biosystems 1.3 91 -8 $ 41,152,012.20
MEM Memphasys Ltd 0.066 29 -8 $ 50,145,076.08
LSH Lifespot Health Ltd 0.1 119 -9 $ 16,846,695.70
PYC PYC Therapeutics 0.15 12 -9 $ 477,138,915.45
NSB Neuroscientific 0.325 41 -11 $ 45,193,567.55
PNV Polynovo Limited 2.465 -4 -11 $ 1,587,331,305.60
HCT Holista CollTech Ltd 0.056 -60 -11 $ 15,419,548.87
AMT Allegra Orthopaedics 0.22 -58 -12 $ 22,981,024.66
ALC Alcidion Group Ltd 0.375 134 -14 $ 393,025,894.50
ONE Oneview Healthcare 0.39 942 -21 $ 164,488,796.14
ACW Actinogen Medical 0.105 329 -32 $ 190,964,232.91
CYC Cyclopharm Limited 1.645 10 -39 $ 156,869,702.64
LDX Lumos Diagnostics 1.3 4 $ 190,693,564.51

Flat this fortnight was 1ST Group (ASX:1ST) – even after announcing a commitment to UN Sustainable Development Goals around digitally transforming healthcare (goal 3) and educating consumers to better manage their health (goal 4).

Cellmid Limited (ASX:CDY) couldn’t move the needle either, putting this down to significant retail disruption in 2H FY21. But the company assures stakeholders it plans to expand its foothold in Chinese markets, launch new ecommerce platforms in the US and Australian and increase Japanese sales growth in FY22.

And Medlab (ASX:MDC) was also flat, even though its NRGBiotic depression study with the Queensland University of Technology (QUT) showed notable mental health outcomes.

Who’s the biggest loser?

Cyclopharm (ASX:CYC) was the biggest loser, down 39% after US Food and Drug Administration (USFDA)unable to approve the new drug application (NDA) for its Technegas product for functional lung ventilation imaging.

The company has to address outstanding technical requirements within 12 months – and once completed – managing director James McBrayer said commercial sales in the US could commence in the second half of 2022.

On the right side of the FDA – but losing 32% was Actinogen (ASX:ACW) whose pre-investigational new drug application (Pre-IND) submission for its Fragile X syndrome (FXS) program was flagged as ‘sufficient’.

The full IND submission is planned in Q3 21, with the Phase II XanaFX 12-week trial investigating the safety and efficacy of Xanamem in male adolescents who suffer from FXS expected to begin in Q4.